The heart has played a central role in COVID-19 since the beginning. Cardiovascular conditions are among the highest risk factors for hospitalization. A significant number of patients hospitalized with SARS-CoV-2 infections have signs of heart damage, and many recover from infection with lasting cardiovascular injury.
It's not surprising that debates over COVID-19 vaccines frequently centre around issues involving cardiovascular health. The high-profile collapse of Danish soccer player Christian Eriksen in June initiated a myth about the link between sudden cardiac death and vaccination among athletes that persists several months later.
Perhaps the most common point of conflict concerning COVID-19 vaccines is the risk of myocarditis following immunization, particularly among young people.
What do the numbers tell us about COVID-19, vaccines and myocarditis?
What is myocarditis?
Myocarditis is an inflammation of the heart muscle most commonly caused by a virus like influenza, coxsackie, hepatitis or herpes. Other causes include bacteria, fungi, toxins, chemotherapy and autoimmune conditions.
Some viruses infect heart muscle and cause direct injury to the heart, while others cause heart damage indirectly through the immune system. Activation of the immune system in response to an infection triggers the release of chemicals in the body called cytokines, which help clear infections. In some cases, the levels of cytokines rise to unusually high levels to produce a "cytokine storm" that causes damage to heart muscle.
Myocarditis by the numbers
Before COVID-19 the incidence of myocarditis was between one and 10 cases per 100,000 people per year. Rates are highest in males between 18 and 30 years old. Interestingly, most cases of myocarditis in the highest risk group are in otherwise healthy and active people.
According to the U.S. Centers for Disease Control and Prevention, the risk of myocarditis after infection with COVID-19 is much higher, at 146 cases per 100,000. The risk is higher for males, older adults (ages 50+) and children under 16 years old. Soccer player Alphonso Davies, 21, of Canada's national men's team, was sidelined by heart inflammation after having COVID-19.
Myocarditis following COVID-19 vaccination is rare and the risk is much smaller than the risks of cardiac injury linked to COVID-19 itself.
Based on a study out of Israel, the risk of post-vaccine myocarditis is 2.13 cases per 100,000 vaccinated, which is within the range usually seen in the general population. This study is consistent with others in the United States and Israel which put the overall incidence of post-vaccine myocarditis between 0.3 and five cases per 100,000 people.
The kids are alright
The highest incidence of myocarditis after vaccination with mRNA vaccines has occurred within three to four days after the second vaccination in males who are under age 30. In pediatric data, the median age is 15.8 years, with most patients being male (90.6 per cent) and white (66.2 per cent) or Hispanic (20.9 per cent). Reliable data on booster shots in this age group is not yet available.
Most studies show a clear benefit of COVID-19 mRNA vaccination with respect to myocarditis. Only one study by Martina Patone, from the University of Oxford, and colleagues found more ambiguous results for those under 40 years of age based on myocarditis rates alone. However, if considering the other ill effects of infection with SARS-CoV-2 - both cardiac and not - there was still a strong benefit in immunizing younger people with COVID-19 vaccines other than Moderna, which research suggests has a higher risk for myocarditis than Pfizer's vaccine.
Repairing the damage
The treatment for myocarditis varies depending on its severity. Adults with mild forms of myocarditis typically need only rest and non-steroidal anti-inflammatory drugs (NSAIDS) like ibuprofen. More severe cases require medications or even mechanical circulatory supports like left ventricular assist devices to support heart function. In some cases when treatment is no longer effective, a heart transplant is required.
In a multicentre series of patients under 21 years old, those with mild symptoms received only NSAIDs or no anti-inflammatory therapy at all. Patients with more severe symptoms can receive stronger therapies including intravenous immunoglobulin, glucocorticoids or colchicine in addition to NSAIDs.
How serious is it?
Over 80 per cent of myocarditis cases not related to COVID-19 or COVID-19 vaccination resolve spontaneously, while five per cent of patients die or require a heart transplant within one year of diagnosis.
Adults who develop myocarditis from COVID-19 have poorer outcomes than non-COVID-19 cases, including a higher risk of death. It should be noted that myocarditis associated with SARS-CoV-2 infection is just one of several heart conditions linked to COVID-19 with outcomes that are worse than non-COVID-19 cases.
In cases of myocarditis following COVID-19 vaccination, the vast majority of cases are mild and resolve quickly. In adults, 95 per cent of cases were deemed to be mild. Similarly, in children, 98.6 per cent are mild, and there has not been any reported need for mechanical heart support (extracorporeal membrane oxygenation, when blood is pumped outside the body to a heart-lung machine) or deaths. All children who had heart weakness had complete normalization of their heart function on followup.
The dynamic changes in the global pandemic, combined with rapid developments in research, make it challenging for the public to take in all the information about the risks and benefits of COVID-19 vaccines. In cases like this it is useful to turn to the guidance of medical organizations whose mandates are to protect the health and welfare of society.
Considering all of the available research, organizations including the American Heart Association, Canadian Cardiovascular Society, Heart and Stroke Foundation of Canada, Canadian Paediatric Society and the American Academy of Pediatrics encourage all who are eligible to be vaccinated against COVID-19.
That's a message we should all take to heart.
Do you have a question about COVID-19 vaccines? Email us at email@example.com and vaccine experts will answer questions in upcoming articles.
Authors: Glen Pyle - Professor, Laboratory of Molecular Cardiology, University of Guelph | Jennifer H Huang - Associate Professor of Pediatric Cardiology, Oregon Health & Science University